The Rel/NF-κB family of transcription factors comprises five members in vertebrates (c-Rel, RelA, RelB, NF-κB1 and NF-κB2). They share a common N-terminal domain involved in DNA binding, homotypic ...

When the genes encoding NF-κB subunits were first isolated, their homology to the previously identified c-Rel proto-oncogene and its viral homologue v-Rel was clear. This provided the first indication ...