Many alphaviruses are medically relevant; chikungunya virus, for example, is an emerging human pathogen responsible for major recent epidemics 3. There are currently no treatments for alphavirus ...

The chikungunya virus virus-like particle (CHIKV VLP) vaccine achieved 100% seroconversion in adults who had previously received alphavirus vaccines and alphavirus vaccine–naive control individuals, ...

Alphaviruses—mosquito-borne viruses that can trigger brain infections and arthritis—may have met their match. Researchers at Washington University School of Medicine in St. Louis have identified two ...

Do a person's antibodies work to block the COVID-19 virus from infecting one's system? Are these antibodies also capable of blocking emerging variants such as the omicrons? These are the questions ...

This report describes a transfection-independent system for packaging alphavirus replicon vectors using modified vaccinia virus Ankara (MVA) vectors to express all of the RNA components necessary for ...

Alphaviruses - mosquito-borne viruses that can trigger brain infections and arthritis - may have met their match. Researchers at Washington University School of Medicine in St. Louis have identified ...

Anti-tumor efficacy and PD-L1 expression in the tumor microenvironment after poxvirus-based active immunotherapy and PD-1 blockade. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I ...

A new study led by researchers at Harvard Medical School has identified a set of cellular receptors for at least three related alphaviruses shared across mosquitoes, humans, and animals that host the ...

The neurotropic alphavirus group includes Eastern equine encephalitis virus (EEEV), Venezuelan equine encephalitis virus (VEEV) and Western equine encephalitis virus (WEEV). These viruses exhibit a ...

Researchers have found antibodies that protect against specific mosquito-borne viruses that cause arthritis and brain infections. The findings could lead to a universal therapy or vaccine for the ...