Leukemia is an umbrella term for multiple different cancers that form in the blood, one such member of the leukemia family being chronic myelogenous leukemia (CML). CML is caused by a chromosomal ...

Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes ...

Translocations are chromosomal "cut and paste" errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Robertsonian chromosomes (ROB) are a type of structurally variant chromosome that is created when two chromosomes fuse together to form an unusual bond. Found commonly in nature, these chromosomes are ...

Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

When couples have trouble conceiving a baby or lose a pregnancy, they often undergo routine tests, which can turn up a shock: One of the prospective parents may be missing a chromosome. The most ...

Recent studies have revealed a surprising diversity of sex chromosomes in vertebrates. However, the detailed mechanism of their turnover is still elusive. To understand this process, it is necessary ...

Genes are segments of DNA (deoxyribonucleic acid) that are located inside every human cell. The DNA inside each cell is tightly coiled in structures called chromosomes. Each chromosome contains a ...

A baby’s genetic makeup is determined when the sperm meets the egg during fertilization. Typically, a full set of DNA is formed, which contains 23 pairs of chromosomes. Sometimes, extra chromosomes ...