SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells.

The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane ...

Bacteria and archaea use protein filament systems to organize cellular processes in time and space. Filaments can act as static scaffolds or as dynamic motors. In some cases, these filament systems ...

Dysfunctions and malformations in the scaffold of a cell are thought to contribute to heart muscle weakness, neurodegenerative disease and even deafness. Now biophysics research at The University of ...

This is a preview. Log in through your library . Abstract Recently, three Chenopodiaceae species, Bienertia cycloptera, Bienertia sinuspersici, and Suaeda aralocaspica, were shown to possess novel C₄ ...

Researchers have identified KIF5A as a new gene associated with the development of amyotrophic lateral sclerosis (ALS). The discovery further implicates the role of cytoskeletal defects in the axon as ...

Actin filaments (F-actin) are key components of sarcomeres, the basic contractile units of skeletal muscle myofibrils. A crucial step during myofibril differentiation is the sequential exchange of ...

Robert Mauck, PhD, from the University of Pennsylvania, discussed how aging and differentiation alter nuclear mechanobiology at the 2014 American Society of Bone and Mineral Research Conference in ...

In the 1950s, advances in microscopy techniques allowed scientists to visualize synaptic communication between two brain cells for the first time. 1,2 However, many details beyond the general synapse ...