The cell division cycle is the sequence of events by which cells faithfully replicate their DNA and then segregate the duplicated chromosomal DNA equally between two daughter cells. An intricate ...
Figure 1: Gβγ-induced autophosphorylation of Erk2 at Thr188. In order to examine whether Gβγ-induced Thr188 phosphorylation plays a part in cardiac hypertrophy, we analyzed mouse hearts 3 weeks after ...
First-in-human study of HMPL-295, an ERK1/2 inhibitor, in patients with advanced solid tumors: Dose-escalation results of monotherapy. This is an ASCO Meeting Abstract from the 2024 ASCO Annual ...
Mitogen-activated protein kinase (MAPK) networks are essential for the transmission of extracellular signals into appropriate intracellular responses. Prototypical MAPK activation implements a ...
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