Notice highlights risks of DPD deficiency with capecitabine, fluorouracil ...
The labeling updates address the risk of early-onset toxicity, including life-threatening adverse events in patients with DPD ...
Complete DPD deficiency markedly impairs 5-FU catabolism, increasing risk of early severe diarrhea, mucositis, neutropenia, ...
Sept. 8, 2004 — The U.S. Food and Drug Administration (FDA) approved in June revisions to safety labeling to advise healthcare professionals of the following changes: estradiol/norethindrone patches ...