Being abundant primary producers, single-celled eukaryotic diatoms and dinoflagellates dominate marine food webs and significantly impact the ecology of the oceans. These organisms face competition ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

G protein-coupled receptors (GPCRs) are seminal transducers of extracellular signals into intracellular responses, orchestrating intricate cascades that regulate cell proliferation, migration and ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

Single-cell proteogenomic analysis defined the lymphoma microenvironment as immune-inflamed, -deficient, and desert, in association with different setpoints of cancer-immunity cycle. EBV interacted ...

Luciferase-based reporter cell lines are invaluable for detecting cellular responses to signaling pathways in vitro, enabling high-throughput screening and profiling of inhibitors or activators. In ...

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...