Intermediate filament proteins constitute a diverse family of cytoskeletal biopolymers. They assemble into durable yet dynamic networks that confer mechanical support, organise subcellular ...

Structures called desmosomes connect cells to each other and transfer mechanical stress. They are especially important in tissues under continual mechanical stress, such as heart muscle (pictured).

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...