This article and associated images are based on a poster originally authored by Teresa Sorbo, Manuel Paina, Manuel Arcangeletti, Katja Blasi, Sara Martin, Donatella Bardelli, Paola Picardi, Fernanda ...
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when lysosomes, the cellular sanitation machines responsible for those tasks, break down or ...
Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular sanitation machines responsible for those tasks, called lysosomes, break ...
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Autophagy and lysosomal pathways orchestrate unconventional secretion of Parkinson's disease protein
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
Oral presentation highlighted the effect of gemfibrozil on Krabbe disease, one of four LSDs in the upcoming Phase 2 SOTERIA basket trial evaluating PLX-200 (reformulated gemfibrozil)PARAMUS, NJ, Feb.
Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...
GBA1 mutations alone do not explain lysosomal dysfunction in PD. Loss of endosomal recycling proteins cripple this lysosomal enzyme. Without a protein called COMMD3, cells spit out would-be lysosomal ...
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