Antigen-presenting cells work to present peptides derived from exogenous and endogenous antigens to circulating T cells, sparking off an immune response. Dendritic cells are unique amongst ...

Figure 1: Immunization with recombinant yeast elicits antigen-specific, T-cell protective, cytotoxic and proliferative responses. Figure 2: DCs internalize yeast and efficiently prime MHC class I- and ...

Researchers found that T cells recognize neoself-antigens -- abnormal, unfolded host proteins presented by major histocompatibility complex II (MHC-II) lacking the invariant chain -- as non-self ...

Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these ...

The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.

T cells play essential effectors and regulatory roles in adaptive immune responses to tumors, viruses, bacteria, parasites, transplanted tissues, allergens and even to self antigens. T cells use the T ...

Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the ...

ROS are key players in the immune system's response to infection and cancer, influencing how the body identifies and fights these threats. A balanced level of ROS supports healthy immune function, but ...

MHC-I presents peptides derived from endogenous antigens. Antigen is proteolyzed by the immune proteasome and specific peptides loaded to MHC-I. The resulting MHC-I–peptide complex is transported to ...

SINGAPORE & SAN DIEGO & OKLAHOMA CITY & AUSTIN, Texas--(BUSINESS WIRE)--ImmunoScape, a pre-clinical biotechnology company focused on the discovery and development of next-generation TCR cell therapies ...

Any substance that induces the immune system to produce antibodies against it is called an antigen. Any foreign invaders, such as pathogens (bacteria and viruses), chemicals, toxins, and pollens, can ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity. This review synthesizes emerging mechanistic evidence showing that ...