Loss-of-function phenotypes often hold the key to understanding the connections and biological functions of biochemical pathways. We and others previously constructed libraries of short hairpin RNAs ...

Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11 exploits this ER-associated protein degradation ...

RNA interference is an effective mechanism for gene silencing whereby double-stranded RNA triggers the cleavage and subsequent degradation of homologous transcript sequences. In this evolutionarily ...

Sigma, a division of Sigma-Aldrich Corporation, through an exclusive agreement with The RNAi Consortium (TRC), has announced the expansion of the MISSION TRC shRNA library product lines to include ...

Influence of obesity on survival in non-metastatic triple negative breast cancer; a retrospective analysis. This is an ASCO Meeting Abstract from the 2016 ASCO Annual Meeting I. This abstract does not ...

Sigma-Aldrich has announced that it is working together with the premier scientific journal Cell to offer the article on High Content Viral Library Screens to a wider audience. Written by principal ...

If our TRC library does not cover the hairpin you need for your research, we can clone a custom sequence for you into the TRC library vector pLKO.1. Contact us by email if you wish to order custom ...