TREM2 - ALZFORUM
TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease …
All Roads Lead to TREM2: Gearing Up to Target This Receptor
Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease. …
Alzheimer's Disease Research Models | ALZFORUM
There is a large ongoing effort to characterize animal models of AD in order to better understand disease pathophysiology as well as to identify models suitable for investigating potential …
Trialists Grapple with How to Outsmart TREM2 | ALZFORUM
Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to …
MS4A Alzheimer’s Risk Gene Linked to TREM2 Signaling
Jul 7, 2018 · Both MS4A and TREM are known AD loci containing a cluster of homologous genes within high linkage disequilibrium blocks, and should be thoroughly investigated for the …
Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
Jan 23, 2023 · TREM2 antibody sports transferrin receptor binding domain to ease entry into brain. It activated microglia and boosted brain glucose metabolism. The antibody is in a first …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership …
TREM2 mutations implicated in neurodegeneration impair cell …
Apr 5, 2019 · Based on a study (Nazmi et al., 2019), TREM2 expression depends upon type I IFN-signaling and the type I IFNs are associated with neuroinflammation. Therefore, it may be …
DNL919 - ALZFORUM
Background This TREM2 agonist antibody activates microglia to phagocytose amyloid. DNL919 contains a transferrin-receptor binding sequence engineered into its Fc domain. Thus, the …
TREM2 R47H - ALZFORUM
Feb 7, 2018 · Ghani M, Sato C, Kakhki EG, Gibbs JR, Traynor B, St George-Hyslop P, Rogaeva E. Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's …