The monoamine hypothesis of depression predicts that the underlying pathophysiologic basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or dopamine in the …

Apr 2, 2018 · Understanding depression pathophysiology is challenging because varying depression symptomatology cannot be explained by single hypothesis. Pathophysiologic …

Feb 9, 2024 · The traditional monoamine theory contends that in addition to common pathogenic factors, deficiencies in monoamine neurotransmitters, such as serotonin (5-HT), dopamine …

This postulated that monoamine levels have a primary role in causing depression, as lowering the levels of monoamines causes depression, while raising them lifts depression (see Hirschfeld …

Nov 26, 2025 · The chemical imbalance hypothesis of depressive symptoms originates with serendipitous findings in the 1950s and 1960s that drugs that decreased levels of …

The monoamine hypothesis posits that depression is due to a deficiency in monoaminergic neurotransmitters such as serotonin (5-HT), norepinephrine (NE), and dopamine (DA) …

3 days ago · If further experimental work can confirm these preliminary findings, physicians may consider revisiting the use of MAOI for the treatment of non-intractable depression because …

6 days ago · We are in the midst of a quiet revolution in the treatment of major depressive disorder. For decades, the research into depression focused on the monoamine hypothesis — …

Abstract The symptoms of depression can be improved by agents that act by various mechanisms to increase synaptic concentrations of monoamines. This finding led to the adoption of the …

Feb 3, 2022 · In this chapter, the most important hypotheses about the biological basis of depression are reviewed. The monoamine hypothesis posits that depression is caused by the …