p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response …

Jan 21, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A …

Mar 28, 2024 · The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated …

Mar 1, 2023 · In this review, we aim to provide a comprehensive summary of the biological function of p53, p53 signaling pathway, the structural features of p53 protein, as well as the …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells …

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and …

Apr 29, 2025 · Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress.

p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for …

Nov 21, 2024 · We propose a model for how DNA binding by p53 is regulated by its disordered regions. Defects in the tumor suppressor protein p53 are found in the majority of cancers.