Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to Harness AI …

TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease (NHD), a …

In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic. In October 2023, the first volunteer was treated in a Phase 1, placebo-controlled, single- and …

Apr 17, 2025 · Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms …

Apr 17, 2025 · TREM2 created quite the buzz at this year’s AD/PD meeting, held April 1-5 in Vienna. In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase …

Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease. Findings …

Background This TREM2 agonist antibody activates microglia to phagocytose amyloid. DNL919 contains a transferrin-receptor binding sequence engineered into its Fc domain. Thus, the antibody binds to …

Feb 7, 2018 · The H157Y mutation reduced activation in response to phospholipid ligands in 2B4 T cells engineered to turn on GFP expression when TREM2 was engaged (Song et al., 2017) and also …

Jan 18, 2018 · The Trem2 −/− (KOMP) mouse was created by the NIH Knockout Mouse Project. In this Trem2 knockout line, the entire coding region of the mouse Trem2 gene was replaced by the lacZ …

Sep 12, 2022 · Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse …