The PI3K AKT signalling pathway

How PI3K and AKT inhibitors are changing breast cancer treatment. | Francisco J. Esteva, MD, PhD posted on the topic | LinkedIn

Breast Cancer Breakthroughs Episode 16: On the Horizon of PI3K Pathway Inhibition

Everyone wants to kill cancer, but almost nobody talks about how cancer actually grows and survives. Cancer growth isn’t random. It uses organized metabolic and signaling pathways to stay alive, divide, and spread. Here are the top 10 growth and survival pathways cancer uses: 1️⃣ Glycolysis / Warburg Effect – Cancer ferments glucose into lactate at a higher rate to fuel rapid growth. 2️⃣ Glutaminolysis – Cancer burns glutamine in the mitochondria to make energy, antioxidants, and building blocks

The Cancer Genome Atlas (TCGA)